A rare congenital malformation: caudal regression syndrome
Cherkaoui Mandour, Brahim El Mostarchid
Corresponding author: Cherkaoui Mandour, Departement Of Neurosurgery, Military Hospital Mohammed V, Rabat, Morocco 
Received: 09 Jan 2013 - Accepted: 14 Jan 2013 - Published: 21 Jan 2013
Domain: Clinical medicine
Keywords: Caudal regression syndrome, congenital malformation, syringomyelia, vertebral agenesis
©Cherkaoui Mandour et al. Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cite this article: Cherkaoui Mandour et al. A rare congenital malformation: caudal regression syndrome. Pan African Medical Journal. 2013;14:30. [doi: 10.11604/pamj.2013.14.30.2364]
Available online at: https://www.panafrican-med-journal.com/content/article/14/30/full
Original article 
A rare congenital malformation: caudal regression syndrome
A rare congenital malformation: caudal regression syndrome
Cherkaoui Mandour1,&, Brahim El Mostarchid1
1Departement Of Neurosurgery, Military Hospital Mohammed V, Rabat, Morocco
&Corresponding author
Cherkaoui Mandour, Departement Of Neurosurgery, Military Hospital Mohammed V, Rabat, Morocco
Caudal regression is a rare syndrome which has a spectrum of congenital malformations ranging from simple anal atresia to absence of sacral, lumbar and possibly lower thoracic vertebrae. It results from a disturbance in the fetal mesoderm in early pregnancy (< 4th week of gestation). Maternal diabetes, genetic predisposition and vascular hypoperfusion have been suggested as possible causative factors but no true causative factor has been determined. Associated organ system dysfunction depends on the severity of the disease. Prenatal ultrasonographic diagnosis of this syndrome is possible at 22 weeks of gestation. We report a case of a four months old male newborn to a known diabetic mother.
Figure 1: Bone reconstruction in 3D that shows a syringomyelia from D4 to D7; terminal myelocystocele (D10); agenesis of D11, D12, lumbar vertebrae, sacrum and coccyx; contiguous appearance of kidneys without prevertebral parenchymal bridge
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