Squamous cell carcinoma in kidney with chronic pyelonephritis and pyelonephrosis: a rare case

Pragyamita Datta

PAMJ. 2023; 45:31. Published 15 May 2023 | doi:10.11604/pamj.2023.45.31.39117

Primary squamous cell carcinoma contributes around 0.5 to 15% of all urothelial malignancy. The predisposing factor and causative agents include renal calculi, infection and endogenous and exogenous chemicals, hormonal imbalance and vitamin A deficiency. A 56-year-old female presented with right flank pain on and off with fever for the last one-week duration, imaging study revealed dilated calyx containing pus material, one focus showing a small whitish nodule. On gross examination, there was a complete loss of architecture, and one portion of calyx showed a friable whitish area and one small nodule measuring 1 x 0.5 cm. Microscopically showing an irregular nest with sheets of malignant squamous cells, differentiating into keratin pearls and background is traversed stromal invasion.
Corresponding author
Pragyamita Datta, Department of Pathology, Jawaharlal Nehru Medical College (DMIHER), Sawangi, Wardha, Maharashtra, India (pragyamita10@gmail.com)

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