Kaplan-Meier product limit technique and Cox-regression analysis to analyze the predictors of survival among patients with colorectal cancer in Jordan: a teaching case-study
1Department of Public Health, Jordan University of Science and Technology, The Eastern Mediterranean Public Health Network (EMPHNET), Jordan
Yousef Khader, Department of Public Health, Jordan University of Science and Technology, The Eastern Mediterranean Public Health Network (EMPHNET), Jordan
In Jordan, the age standardized rate (ASR) of colorectal cancer (CRC) has increased from 12.6 per 100,000 in 2005 to 17.2 per 100,000 in 2010. According to the latest comprehensive cancer incidence report in 2012, CRC accounted for 11.3% of all newly diagnosed cases among Jordanians, and ranked the second among all cancers in both genders. The overall crude incidence rate was 8.9/100,000 population (8.6 and 9.2/100,000 males and females, respectively). The overall ASR was 16.3/100,000 (15.9 and 16.6/100,000 males and females, respectively). According to Jordan mortality registry in 2013, neoplasms were the second leading cause of death (16.4% of total deaths), and cancer of small intestine, colon, rectum and anus accounted for 2% of total deaths. This case study demonstrates the practical application of basic and advanced statistical techniques to conduct survival analysis. This case study is designed for the training of basic level field epidemiology trainees or any other health care workers working in public health-related fields. It can be administered in 5-7 hours in class or as a take-home exercise.
How to use this case study
General instructions: this case study should be used as adjunct training material for novice epidemiology trainees to reinforce the concepts taught in prior lectures. The case study is ideally taught by a facilitator in groups of about 20 participants. It can be administered as a take-home assignment or part of an examination assignment. This assignment require analysis and writing from the student.
this case study was developed for novice field epidemiology students. These participants are commonly health care workers working in the county departments of health whose background may be as medical doctors, nurses who work in public health-related fields. Most have a health science or medical statistics background is preferred.
before using this case study, participants should have received lectures on survival analysis.
flash drive, flip charts, markers, computers, SPSS software
Case study material
- Download the case study student guide
- Request the case study facilitator guide
The authors declare no competing interests.
Authors would like to acknowledge The Eastern Mediterranean Public Health Network (EMPHNET) for their technical support.
Annex 1: SPSS file survival analysis
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- the American Cancer Society, Atlanta, Georgia. Colorectal Cancer Facts & Figures 2014-2016. Accessed on 16 March 2019.
- Jordan cancer registry reports (2006-2010). Accessed on 16 March 2019.
- JCR, MOH. Annual Incidence of Cancer 2012. Accessed on 16 March 2019.
- Ministry of health, Jordan. Annual Mortality Report in 2013, Ministry of health, Jordan. Accessed on 16 March 2019.
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