A rare image of zinc-responsive acral hyperkeratosis
Abhishek Patil, Sourabh Deshmukh
Corresponding author: Abhishek Patil, Department of Kayachikitsa, Mahatma Gandhi Ayurved College Hospital and Research Centre, Salod (H), Wardha, Datta Meghe Institute of Higher Education and Research, Maharashtra, India
Received: 26 Oct 2024 - Accepted: 06 Dec 2024 - Published: 15 Jan 2025
Domain: Dermatology
Keywords: Hepatitis C infection, necrolytic acral erythema, zinc
©Abhishek Patil et al. Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cite this article: Abhishek Patil et al. A rare image of zinc-responsive acral hyperkeratosis. Pan African Medical Journal. 2025;50:27. [doi: 10.11604/pamj.2025.50.27.45731]
Available online at: https://www.panafrican-med-journal.com//content/article/50/27/full
A rare image of zinc-responsive acral hyperkeratosis
&Corresponding author
Acral hyperkeratosis that responds to zinc usually manifests as symmetrically distributed, long-lasting, well-defined hyperpigmented plaques over the acral areas of the body. It is a condition that causes thickening of the skin on the hands and feet. Zinc deficiency can be a cause of acral hyperkeratosis. A 50-year-old man came in with a six-month-old, slightly itchy, scaly, raised lesions over both feet which were darkly coloured and somewhat irritating. A cutaneous examination of the dorsum of the feet revealed bilaterally symmetrical, well-demarcated hyperpigmented plaques. The patient was treated using oral zinc with 200mg of zinc sulfate twice daily and 10% urea-containing emollient for local application. He got significant relief from raised lesions and hyperpigmented plaques.
Figure 1: feet with raised lesions and hyperpigmented plaques