Verrucous epidermal nevus
Gerardo Rivera-Silva, María Guadalupe Moreno-Treviño
Received: 04 Jul 2023 - Accepted: 27 Jul 2023 - Published: 02 Aug 2023
Domain: Dermatology,Pediatrics (general)
Keywords: Epidermal nevus, verrucous epidermal nevus, histopathology
©Gerardo Rivera-Silva et al. Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cite this article: Gerardo Rivera-Silva et al. Verrucous epidermal nevus. Pan African Medical Journal. 2023;45:146. [doi: 10.11604/pamj.2023.45.146.40966]
Available online at: https://www.panafrican-med-journal.com/content/article/45/146/full
Verrucous epidermal nevus
A 9-year-old male presented with an asymptomatic, confluent, and hyperpigmented skin lesion on the right lateral trunk region presented at birth. No changes in color and consistency are reported, except that the lesion enlarged in proportion to the patient's growth. The mother informed us that the patient was diagnosed with anxiety one year ago. Physical examination revealed a large, hyperpigmented, and confluent patch of overgrown skin with a dimension between 20cm long and 15cm wide associated with painless verrucous plaques located on the right lateral trunk region (A). The laboratory investigations revealed a H1047R mutation in the PIK3CA gene. The anatomopathological study showed hyperkeratosis, acanthosis, and papillomatosis compatible with verrucous epidermal nevi (hamartomas). Anteroposterior (B) and lateral (C) neck radiographs revealed left convexity scoliosis. Based on the clinical, pathologic findings, the lesion was diagnosed as verrucous epidermal nevus (VEN). This malady is benign and congenital and could be associated with abnormalities in neurologic, ophthalmologic, or skeletal systems. When this type of nevi is located on the trunk, is associated with alterations in the bone curvatures of the spine, and/or in the bones of the arms or legs due to mutations in the PIK3CA gene, as in our case. The treatment was a shave excision followed by a phenol peeling medical; although, it is not possible to predict when skin lesions will recur.
Figure 1: A) general appearance of the nevus, showing the hamartomas; B) cervical radiological images of anteroposterior; C) lateral views, showing left convexity scoliosis