Images in clinical medicine | Volume 37, Article 332, 10 Dec 2020 | 10.11604/pamj.2020.37.332.26648

An unusual presentation of an oral HPV lesion

Cinzia Casu, Antonello Mameli

Corresponding author: Cinzia Casu, Department of Surgical Science, OBL Oral Biotechnology Laboratory, University of Cagliari, Cagliari, Italy

Received: 24 Oct 2020 - Accepted: 20 Nov 2020 - Published: 10 Dec 2020

Domain: Stomatology

Keywords: Oral HPV lesion, squamous papilloma, oral HPV, lichen planus

©Cinzia Casu et al. Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this article: Cinzia Casu et al. An unusual presentation of an oral HPV lesion. Pan African Medical Journal. 2020;37:332. [doi: 10.11604/pamj.2020.37.332.26648]

Available online at: https://www.panafrican-med-journal.com/content/article/37/332/full

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Images in clinical medicine

An unusual presentation of an oral HPV lesion

An unusual presentation of an oral HPV lesion

Cinzia Casu1,&, Antonello Mameli1

 

1Department of Surgical Science, OBL Oral Biotechnology Laboratory, University of Cagliari, Cagliari, Italy

 

 

&Corresponding author
Cinzia Casu, Department of Surgical Science, OBL Oral Biotechnology Laboratory, University of Cagliari, Cagliari, Italy

 

 

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A 45-year-old male patient went to our observation for a white lesion in the left lower gum. At the anamnesis he reported previous diagnosis of oral erosive and genital lichen planus (discovered 2 and 12 years before respectively) and the excision of 2 small oral squamous papillomas 2 year ago. A PCR-real time test using a saliva sample was carried out a year ago, but it did not confirm the presence of the HPV DNA. During the clinical examination we observed a white not scrapable lesion of 2.2cm in the vestibular gum around the teeth 3.6-3.7. The lesion is not linked with a traumatic event and we decided to make an incisional biopsy to verify if it was another injury linked to the spread of oral erosive lichen planus or a new entity. The histological examination confirmed a diagnosis of oral HPV lesion, precisely squamous papilloma, but in-situ hybridation did not find HPV DNA. The presence of a mild dysplasia with unaffected margins was also confirmed. At our first knowledge, this is the first documented case in literature of an oral squamous papilloma with a keratin-like appearance, rather than exophytic and/or cauliflower form. The differential diagnosis could be with oral lichen planus, leukoplakia or verruca vulgaris. The patient was advised of the risk of malignancy connected with the simultaneous presence of oral erosive lichen planus and HPV lesions.

 

 

Figure 1: particular presentation of a relapse of squamous papilloma

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Images in clinical medicine

An unusual presentation of an oral HPV lesion

Images in clinical medicine

An unusual presentation of an oral HPV lesion

Images in clinical medicine

An unusual presentation of an oral HPV lesion

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Key words

Oral HPV lesion

Squamous papilloma

Oral HPV

Lichen planus

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An unusual presentation of an oral HPV lesion