Complications of breast cancer surgery at Conakry oncological surgery unit
Bangaly Traore1,&, Adama Madany Diarra2, Mamady Keita1
1Surgical Oncology Unit of Donka, Faculty of Health Sciences and Technology, University Gamal Abdel Nasser of Conakry, Conakry, Guinea, 2Faculty of Medical and Paramedical Sciences, Koffi Annan University of Guinea, Conakry, Guinea
Bangaly Traore, Surgical Oncology Unit of Donka, Faculty of Health Sciences and Technology, University Gamal Abdel Nasser of Conakry, Conakry, Guinea
To analyze surgical complications and their impact on the prognosis of operated breast cancer patients. This was a retrospective cohort study of breast cancer patients who underwent radical breast cancer surgery (RBS) or conservative breast cancer surgery (CBS) with axillary lymph node dissection. The oncological surgery unit of Donka National Hospital served as a framework for this study from January 2007 to December 2016. A total of one hundred and thirteen patients, including 111 women and 2 men were operated during the study period. The cancer was stage III in 92 (81.1%) cases. RBS was performed in 103 (91.1%) patients and CBS in 10 (8.9%) patients. Of the patients, 92.5% had neoadjuvant chemotherapy, 68.5% had adjuvant chemotherapy, 33.6% had adjuvant radiotherapy and 39.8% hormone therapy. Surgery was complicated by intraoperative hemorrhage in 2 (2.1%) cases. Early postoperative complications included pain 47 (50%), seroma 14 (14.9%), delayed healing 13 (13.8%), hematoma 9 (9.6%), infection 2 (2.1%) and embolism 2 (2.1%). Late complications includedrelapse in 59 (52.2%), brachial pain in 23 (20.4%), lymphedema in 19 (16.8%) and shoulder movement limitations in 8 (7.1%). There was 27.1% of relapsesoccurred in patients with lymphedema versus 5.7% in the absence of lymphedema (p=0.002). The overall mortality was 59 (52.2%), including 4 (3.5%) postoperative cases. Operative pain, seroma, lymphedema and recurrence were the most common complications. This study showed that the high risk of death was related to the occurrence of relapse, more commonly seen in patients with lymphoedema.
Breast cancer is the leading cause of consultation in the surgical oncology unit and accounts for 27.3% of all cancers . Despite this high frequency of breast cancer, very few are operated on because of the advanced stage which requires neodadjuvant chemotherapy which is less accessible to patients. Breast cancer treatment is multidisciplinary, combining locoregional and systemic therapies. Breast surgery, combined with other methods of treatment, can cure patients. In developing countries, the frequency of complications related to treatment can reach 28.95% . The objectives of this study were to analyze complications related to surgical treatment and their impact on the functional and vital prognosis of breast cancer surgery in our setting.
This retrospective cohort study included 113 patients, operated and followed up for breast cancer at the oncology surgery unit of Donka National Hospital from 2007 to 2016. We included breast carcinomas and breast sarcomas for which a modified radical mastectomy or conservative breast surgery with axillary lymph node dissection were performed. Patient characteristics (age, sex) and tumor node metastasis (TNM) stage have been described. In stage III breast cancer, we performed neoadjuvant chemotherapy upfront modified radical mastectomy, whereas stages I and II breast cancer patients benefited from first-line surgery. Adjuvant treatments (chemotherapy, radiotherapy) were noted.
The follow-up time was defined by the difference, in months, between the date of the surgical procedure and the date of the last postoperative consultation. Surgical complications were classified into intraoperative (during operation) and early (within 30 days after breast surgery) andlate (beyond 30 days after surgery) postoperative complications. Factors and corrective measures associated with the complications were described. Deaths and their cause were reported. We assessed the prognosis on the occurrence of relapse,with the recurrence and survival times.
All statistical analyses were performed using SPSS version 21.0 software (Inc., Chicago, IL). Qualitative data were represented as proportions (%) and quantitative as average (± standard deviation) or median with interquartile interval range (IQR). The Fischer and Chi2 test were performed to analyze factors associated with complications. Survival ratewascalculated according to the Kaplan Meir method. The log rank test was performed to compare survival differences according to relapse. The difference was significant if the p-value was less or equal to 0.05.
A total of 113 breast cancer patients were collected, including 111 (98, 2%) women and 2 (1.8%) men. Their age ranged from 20 to 85 years, with an average of 48.2 (± 13.75) years. There were 112 carcinomas and one sarcoma. The tumor was classified T3-T4 in 99 (87.6%) cases and stage III accounted for 93 (82.3%) cases (Table 1). The average time to surgery was 6.4 months after the diagnosis of breast cancer (IQR 4.0- 8.0). RBS was performed in 103 (91.6%) cases and CBS in 10 cases (8.8%). The mean time to hospitalization was 7.9 days (± 4.2). One hundred patients (92.5%) received neoadjuvant chemotherapy, 74 (68.5%) adjuvant chemotherapy and 38 (33.9%) received adjuvant radiotherapy. Radiation therapy was achieved in 40% of patients with conservative surgery versus 33.3% with radical surgery.
The mean follow-up time was 47.9 months (± 3.1). Intraoperative complications occurred in 2 (1.7%), early postoperative in 64 (56.6%) and late complications in 68 (60.2%) patients (Table 2).
Intraoperative complications were 2 cases of hemorrhage, including one case per axillary vein wound.
Early postoperative complications included pain 47 (50%) case, seroma 14 (14.9%) case, delayed healing 13 (13.8%) case, hematoma 9 (9.6%) case, operative wound infection (OWI) 2 (2.1%) cases and embolism 2 (2.1%). In 13 (13.8%) cases, delayed healing was associated with cutaneous necrosis (7 cases), suppuration (2 cases) and seroma (4 cases). Late complications included 59 (62.8%) recurrences, 23 (24.5%) brachial pain, 19 (20.2 lymphedema and 8 (8.5%) shoulder movement limitations. Brachial pain was observed in 7 (50.0%) patients who had seromas versus 16 (16.3%) who did not have seromas (p=0.008). In addition, brachial pain dependedupon lymphedema, 4 (21.1%) versus 4 (4.3%) (p=0.027). Of the eight patients with shoulder movements limitation, 17.4% occurred in patients who had brachial pain compared to 44.9% patients did not have brachial pain (p=0.054). During the follow-up time, 19 (20.2%) patients developed lymphedema and 59 (60.8%) relapsed. The recurrence was local (chest wall) in 2 (3.4%) cases, locoregional in 8 (13.6%) cases and metastatic in 32 (54.2%) cases. The median time to recurrence was 8.5 months (IQR 4.0-13.2). The recurrencewas seen in 16 (84.2%) who had lymphedema versus 43 (46.7%) who did not have lymphedema (p=0.005).
During the follow-up period, 54 (47.8%) were alive while 59 (52.2%) died. Four patients (4.3%) died after surgery and the causes were pulmonary embolism (1 case), acute pulmonary edema (1 case) and cardiopulmonary arrest (2 cases). The five-year overall survival rate was 25%. This survival was 15% in patients with recurrence and 47% in those without recurrence, respectively (p=0.005).
In this study, we analyzed the complications after surgical treatment of 113 patients who underwent breast cancer resection surgery from 2007 to 2016. The results showed a high prevalence of complications after curative surgery in breast cancer in our study. Zongo et al.  noted 28.95% of complications after breast cancer surgery in Burkina Fasso, while Ogundiran et al.  reported 14.5% in Nigeria. These differences may be explained by the fact that these studies do not take into account both intraoperative and postoperative (early and late) complications.
Despite the high prevalence of operative complications, we estimate that there is underreporting of bleeding cases in this study. Breast surgery, whether conservative or radical, is always accompanied by blood loss. Apart from active bleeding, the comparison of hemoglobin levels, before and after surgery, may thoroughly evaluate operative hemorrhage. These hemorrhagic complications can reach 25% during mastectomy for breast cancer . Surgical hemorrhagic risk can be assessed according to breast volume and infiltration of breast and surrounding tissues . The prevalence of hematoma varies from 5 to 10% . The cause could be due to imperfect hemostasis. Patients were not exposed to antiplatelet agents or anticoagulants. In the majority of cases, it was a simple hematoma. Only one case required drainage of the hematoma.
Early postoperative pain is more common (60%) than late postoperative pain (10%) . Nearly half of the patients had early postoperative pain. This high frequency of postoperative pain, often nociceptive typewas related to the non-availability of morphine. In the absence of morphine, paravertebral blocks could minimize these postoperative pains and even the consumption of analgesics . Other patients had chronic pain in the chest wall, axilla or shoulder on the operated breast side. These pains were more common in patients who had seroma and lymphedema in this study. The brachial pain, although calmed by level 2 analgesics are also due to nerve damage by the sacrifice of Charles Bell nerve and that of thepectoralisminor. The persistent nature despite symptomatic treatment should indicate the prescription of co-analgesics such as antidepressants, anticonvulsants or neuroleptics. Two patients who had embolism were under heparin and observed early mobilization. Andtbacka et al.  reported 0.16% within 60 days after breast cancer surgery. OWI were less common in this study. The rate of OWI was similar to that of other studies in Nigeria and Ivory Coast, which found 4.4 and 3.4%, respectively [3,4]. In some studies, the rate OWI was more frequent, probably over 5% or more than 10% [10-12]. The low rate of infection in our study could be explained by the systematic antibioprophylaxis treatment, the removal of the drain within 4 to 5 days after surgery, the precautions of asepsis and the quality of postoperative care. Consideration of Alteimer classes and the comorbidities (diabetes, obesity, HIV infection) could also help to minimize the risk of OWI in breast cancer surgery .
After the pain, seroma was the most common early postoperative complication in this study. The seroma is a complication of both mastectomy and axillary lymph node dissection. Similar results were reported by Abass et al.  in Sudan, who found 15.6% seroma after breast cancer surgery. Others studies reporteda high frequency of seroma, ranged from 33 to 43.6% despite axillary and prepectoral double drainage [14-16]. In contrast to our study, a correlation wasfound between seroma occurrence and obesity . Lymphedema is a chronic and sometimes disabling complication. It was the second late operative complication after chronic pain. The risk of lymphedema was correlated with the level of cleaning and lymph node involvement [6,8]. The frequency varies from 10 to 27% [4,18]. The cumulative risk over five years is 42%, according to Norman et al. . The high frequency in our study could be explained by the fact that we perform axillary node dissectionof the level II and III of berg because of advanced stages of breast cancer. In this study, there was no significant difference in the occurrence of lymphedema after adjuvant radiotherapy. It was the same as in the study by Ay et al. . But adjuvant radiotherapy is a risk factor for lymphedema in other studies . The evolution of lymphedema is sometimes enameled with episode of lymphangitis and cellulitis  as it was the case in one of our patients who had phlegmon in her arm.
Continuous physiotherapy is the only therapeutic weapon that minimizes disabling complications of lymphedema . The limitations of shoulder movements in less than 10% of our patients could be related to insufficient rehabilitation of the upper limb. This complication is more common in some studies, reaching up to 48% . They are more frequent in radical than in conservative breast surgery, even more so after axillary lymph node dissection. The introduction of early physiotherapy after breast surgery, by acting on the movements, adduction, abduction and shoulder rotation is the best prevention of this complication .
We observed a very high recurrence rate. Sahraoui et al.  observed in Tunisia, a recurrence rate of 4.84%. Buschanan et al.  found 8.8% of locoregional recurrence after mastectomy. The recurrence rate was high during the first year. This rate was high for advanced stages without significant difference. In a single institution review, factors found to be associated with recurrence in our previous study were age and stage at diagnosis . Moreover, we found a significant correlation between the occurrence of relapse and lymphedema. To the best of our knowledge, there are no reported data on the relationship between breast cancer relapse and the onset of lymphedema. Mortality was 4.2% in our study while it was zero in some studies in Nigeria . In this study, all four deaths were related to cardio-pulmonary and thromboembolic causes.
Operative pain, seroma, lymphoedema and recurrence were the most common complications. This study showed that the risk of death was related to the occurrence of relapse, which is more frequently observed in patients with lymphedema.
What is known about this topic
- Breast cancer surgery may cause complications such as recurrence, lymphedema and seroma.
What this study adds
- The occurrence of lymphedema was correlated with a locoregional recurrence.
The authors declare no competing interests.
All authors contributed to the design and writing of this study. All the authors have read and agreed to the final manuscript.
We thank Mr Balde Thierno and all the team of surgical oncology unit for the good preservation of patient records.
Table 1: characteristics of breast cancers
Table 2: distribution of the operative complications according to breast cancer surgery (n=113)
- Traoré B, Keita M, Diane S, Dankoro A, Kabba IS, Keita N. Clinicopathological study of breast diseases presenting to the surgical oncology unit of Donka University Hospital in Conakry, Guinea. West Afr J Med. 2012;31(4):227-31. PubMed | Google Scholar
- N'guessan YI, Dia Jean-Marc L, Toure M, Corneille ST, Gilbert TS, Adunfé OM et al. Review of mastectomy in the department of gynecology at the Treichville teaching hospital, Abidjan-Cote d'Ivoire. Int J Reprod Contracept Obstet Gynecol. 2018;7(4):1313-1317.
- Ogundiran TO, Ayandipo OO, Ademola AF, Adebamowo CA. Mastectomy for management of breast cancer in Ibadan, Nigeria. BMC Surg. 2013;13:59. PubMed | Google Scholar
- Zongo N, Millogo-Traore TF, Bagre SC, Bagué AH, Ouangre E, Zida M et al. Place of surgery in the treatment of breast cancer in women at University Hospital Yalgado Ouedraogo: about 81 cases. Pan African Medical Journal. 2015;22:117. PubMed | Google Scholar
- Clegg-Lamptey JN, Dakubo JCB. Mastectomy blood loss: can We predict the need for blood transfusion. Int J Clin Medicine. 2014;5(20):1294-1299. Google Scholar
- Vitug AF, Newman LA. Complications in breast surgery. Surg Clin North Am. 2007;87(2):431-51. PubMed | Google Scholar
- Fecho K, Miller NR, Merritt SA, Klauber-Demore N, Hultman CS, Blau WS. Acute and persistent postoperative pain after breast surgery. Pain Med. 2009;10(4):708-15. PubMed | Google Scholar
- Bhuvaneswari V, Wig J, Mathew PJ, Singh G. Post-operative pain and analgesic requirements after paravertebral block for mastectomy: a randomized controlled trial of different concentrations of bupivacaine and fentanyl. Indian J Anaesth. 2012;56(1):34-39. PubMed | Google Scholar
- Andtbacka RH, Babiera G, Singletary SE, Hunt KK, Meric-Bernstam F, Feig BW et al. Incidence and prevention of venous thromboembolism in patients undergoing breast cancer surgery and treated according to clinical pathways. Ann Surg. 2006;243(1):96-101. PubMed | Google Scholar
- Shaikh S, Fatima J, Shakil S, Rizvi SM, Kamal MA. Antibiotic resistance and extended-spectrum bêta-lactamases: types, epidemiology and treatment. Saudi J Biol Sci. 2015;22(1):90-101. PubMed
- Gil-Londoño J-C, Nagles-Pelaez J-A, Maya-Salazar W-A, Madrid J, Maya-Restrepo M-A, Agudelo-Pérez R-A et al. Surgical site infection after breast cancer surgery at 30 days and associated factors. Infect. 2017;21(2):96-101. Google Scholar
- Nyaoncha A, Wasike R, Ahmed M, Njihia B. Surgical site infection rates in breast cancer surgery at a university hospital in Nairobi, Kenya. Clin Oncol. 2016;1:1069.
- Abass MO, Gismalla MDA, Alsheikh AA, Elhassan MMA. Axillary lymph node dissection for breast cancer: efficacy and complication in developing countries. J Glob Oncol. 2018;4:1-8. PubMed | Google Scholar
- Bokhari I, Mehmood Z, Nazeer M, Khan A. Early complications of mastectomy with axillary clearance in patients with stage Ii and Iii carcinoma. Breast Journal of Surgery Pakistan (International). 2010;15(4):182-185. Google Scholar
- Dahri FJ, Awan MS, Qazi AR, Khaskheli NM, Soomro IA. Early wound complications following modified radical mastectomy with axillary clearance. J Surg Pakistan (International). 2011;16(4):165-169. Google Scholar
- Sasic M, Inic M, Vukotic D, Buta M, Jevric M, Sasic J. 362 poster complications related to the radical mastectomy. EJSO. 2006;32(Suppl 1):S108. Google Scholar
- Soyder A, Tastaban E, Özbas S, Boylu S, Özgün H. Frequency of early-stage lymphedema and risk factors in postoperative patients with breast Ccancer. J Breast Health. 2014;10(2):92-97. PubMed | Google Scholar
- Ay AA, Kutun S, Cetin A. Lymphoedema after mastectomy for breast cancer: the importance of supportive care. S Afr J Surg. 2014;52(2):41-4. PubMed | Google Scholar
- Norman SA, Localio AR, Potashnik SL, Simoes Torpey HA, Kallan MJ, Weber AL et al. Lymphedema in breast cancer survivors: incidence, degree, time course, treatment and symptoms. J Clin Oncol. 2009;27(3):390-7. PubMed | Google Scholar
- Warren LE, Miller CL, Horick N, Skolny MN, Jammallo LS, Sadek BT et al. The impact of radiation therapy on the risk of lymphedema after treatment for breast cancer: a prospective cohort study. Int J Radiat Oncol Biol Phys. 2014;88(3):565-71. PubMed | Google Scholar
- Agbenorku P. Lymphedema: complications and management. Surgical Science. 2014;5:290-298. Google Scholar
- Sugden EM, Rezvani M, Harrison JM, Hughes LK. Shoulder movement after the treatment of early-stage breast cancer. Clinical Oncology (R Coll Radiol). 1998;10(3):173-181. PubMed | Google Scholar
- Box RC, Reul-Hirche HM, Bullock-Saxton JE, Furnival CM. Shoulder movement after breast cancer surgery: results of a randomized controlled study of postoperative physiotherapy. Breast Cancer Res Treat. 2002;75(1):35-50. PubMed | Google Scholar
- Sahraoui W, Essafi A, Laajili H, Haouas N, Hmissa S, Sebri L et al. Prognosis of local recurrence of breast cancer in Tunisia. Tunis Med. 2006;84(2):97-102. PubMed | Google Scholar
- Buchanan CL, Dorn PL, Fey J, Giron G, Naik A, Mendez J et al. Locoregional recurrence after mastectomy: incidence and outcome. J Amcoll Surg. 2006;203(4):469-74. PubMed | Google Scholar
- Traore T, Toure A, Sy T, Dieng M, Condé M, Deme A et al. Prognosis of breast cancer patients underwent surgery in a developing country. Journal of Cancer Therapy. 2015;6:803-810. Google Scholar