Original article | Volume 33, Article 250, 24 Jul 2019 | 10.11604/pamj.2019.33.250.16922

Rare involvement of paranasal sinuses in sarcoidosis: case report and literature review

Afnan Rajeh, Andreas Albers, Annett Pudszuhn, Veit Maria Hofmann

Corresponding author: Afnan Rajeh, Department of Otorhinolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany

Received: 26 Aug 2018 - Accepted: 05 May 2019 - Published: 24 Jul 2019

Domain: Otolaryngology (ENT)

Keywords: Sarcoidosis, paranasal sarcoidosis, sinonasal involvement, treatment of sarcoidosis

©Afnan Rajeh et al. Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this article: Afnan Rajeh et al. Rare involvement of paranasal sinuses in sarcoidosis: case report and literature review. Pan African Medical Journal. 2019;33:250. [doi: 10.11604/pamj.2019.33.250.16922]

Available online at: https://www.panafrican-med-journal.com/content/article/33/250/full

Home | Volume 33 | Article number 250

Original article

Rare involvement of paranasal sinuses in sarcoidosis: case report and literature review

Rare involvement of paranasal sinuses in sarcoidosis: case report and literature review

Afnan Rajeh1,&, Andreas Albers1, Annett Pudszuhn1, Veit Maria Hofmann1

 

1Department of Otorhinolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany

 

 

&Corresponding author
Afnan Rajeh, Department of Otorhinolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany

 

 

Abstract

Sarcoidosis is a non-caseating inflammatory chronic systemic disease of unknown etiology, which may affect one or more organs. Paranasal sinuses involvement occurs sporadic in sarcoidosis. We report a patient with a medical history of sarcoidosis involving her lungs, liver, and lymphatic system for four years who now presented with nasal and sinuses symptoms. The primary treatment with local cortisone showed no improvement. Computed tomography (CT) scan of the paranasal sinuses (PNS) revealed signs of chronic pansinusitis. She was successfully treated with endoscopic sinonasal surgery. Subsequent histological analysis confirmed the involvement of the PNS with sarcoidosis. Her follow-up during the last 6 months was without recurrence.

 

 

Introduction    Down

Sarcoidosis is a multisystemic inflammatory disease of unknown etiology, which may involve any organ in the body [1-3]. Involvement of lungs and intrathoracic lymph nodes is present in more than 90% of the cases [1, 4], while a sinonasal association occurs in less than 5% of the reported sarcoidosis cases [5-10]. Published studies differ in determining the diagnosis of paranasal sarcoidosis depending on symptoms, nasal endoscopy, computed tomography (CT) of sinuses or histology. This report aims to emphasize that even though paranasal sinuses (PNS) involvement is rare, it is an important site of manifestation and symptoms can be treated by functional endoscopic sinus surgery and medication as required by the stage of the disease and nasal or prenasal thickness (PT) involvement respectively.

 

 

Patient and observation Up    Down

A 31 year old woman presented with left-sided nasal obstruction and pressure pain in the left maxillary sinus and forehead for six months. She was diagnosed four years ago with sarcoidosis with involvement of the lungs and liver, hilar lymphadenopathy, as well as iritis. CT of the PNS showed typical signs of chronic left maxillary, anterior ethmoidal, and frontal sinusitis (Figure 1). Since conservative topical therapy with cortisone had failed, the patient was treated surgically with functional endoscopic sinus surgery (FESS). Histology revealed mucosal granulation with sarcoidosis involvement. The endoscopic follow-up six months after the operation showed no recurrence. After the initial healing phase, the patient reported significant improvement of all symptoms.

 

 

Discussion Up    Down

While sarcoidosis mainly involves the lower respiratory tract, it rarely affects the PNS. Until 2013 more than 15 studies including about 5000 sarcoidosis patients described occurrence of sinonasal sarcoidosis (SNS) in about 4.5% [1-15]. However, the reported incidence may remain inaccurate for several reasons: either because of the similarity of symptoms compared to nonsarcoid rhinosinusitis, or the physicians lack awareness of such rare involvement by sarcoidosis and therefore inadequate association of sinusitis symptoms with the disease and radiologic diagnostics [7,16]. Bock first reported the SNS in 1905, and the first sinonasal involvement was reported by Schaumann in 1924 and 1926 [17]. A review by Long et al. in 2001 of 6 patients with pulmonary sarcoidosis showed four patients with histologically proven SNS [11]. Others found a lower incidence of SNS of 1% out of 1388 of the reported cases, where the significant symptoms were similar to the chronic rhinosinusitis symptoms such as nasal stiffness, rhinorrhea, epistaxis, facial pain, and anosmia [13,15,16].

 

Histologically, paranasal sarcoidosis is characterized by non-caseating granulomatous inflammation which may occur before systemic manifestation of sarcoidosis [10,15,16]. Reported CT scan findings of the PNS were mucosal thickening, sinus opacification, inflammatories like distraction and bone erosions [2,3,11,14]. In 2004 Braun et al. proposed clinical and radiologic criteria for the diagnosis of histologically proven SNS deduced from the study of 15 SNS patients with retrospectively involvement. The radiological criteria were presence of nodules on the septal or turbinate mucosa, nasopharyngeal or pharyngolaryngeal lesions, and complete or subtotal opacification of the sinuses and/or the nasal cavities [3]. Initial treatment of SNS may include topical or systemic steroid therapy and in cases of acute or chronic sinusitis FESS is recommended. The role of FESS in chronic sinonasal sarcoidosis was reported by Kay et al. in 2001, where only 7% of 86 patients were treated with FESS [18]. Lately, in 2013, Kirsten A et al. presented a retrospective analysis of 12 biopsy-proven cases, where the conservative treatment with topical and systemic corticosteroid following sinuses surgery was successful in most patients. Only 4 of them had repeated surgery because of symptoms persistence [15].

 

 

Conclusion Up    Down

SNS was found in 4.5% of reported cases worldwide. The clinical presentation included nasal obstruction, epistaxis, rhinorrhea or facial pain. The treatment consisted of local and systemic steroid therapy and in some cases sinus surgery. Sinonasal involvement in patients with sarcoidosis is an important manifestation that can be treated successfully. Thus it should be considered in every cased since SNS may be underdiagnosed.

 

 

Competing interests Up    Down

The authors declare no competing interests.

 

 

Authors' contributions Up    Down

All the authors took part in the realization and the implementation of this work. They also state that they have read and approved the final version of this work.

 

 

Figure Up    Down

Figure 1: A) sinonasal CT coronal and B) sagittal views in a patient with SNS shows mucosal thickenings of the left maxillary, anterior ethmoidal, and the frontal sinuses as indicated by arrows.

 

 

References Up    Down

  1. Baughman RP, Lower EE, du Bois RM. Sarcoidosis. Lancet. 2003; 361(9363):1111-1118. PubMed

  2. Bourjat P, Braun J. Sinonasal sarcoidosis: CT evaluation. J Radiol. 2002;83(4 Pt 1):467-471. PubMed | Google Scholar

  3. Braun JJ, Gentine A, Pauli G. Sinonasal sarcoidosis: review and report of fifteen cases. Laryngoscope. 2004;114(11):1960-1963. PubMed | Google Scholar

  4. Newman LS, Rose CS, Maier LA. Sarcoidosis. N Engl J Med. 1997;336(2):1224-1234. PubMed

  5. James DG, Barter S, Jash D, MacKinnon DM, Carstairs LS. Sarcoidosis of the upper respiratory tract (SURT). J Laryngol Otol. 1982;96(8):711-718. PubMed | Google Scholar

  6. McCaffrey TV, McDonald TJ. Sarcoidosis of the nose and paranasal sinuses. Laryngoscope. 1983;93(10):1281-1284. PubMed | Google Scholar

  7. Meybeck A, Just N, Heurtebise F, Chanez P, Crampette L, Darras J, Wallaert B. Involvement of the nasal sinuses in sarcoidosis: a prospective study of 63 patients. Rev Mal Respir. 2004;21(2 Pt 1):279-286. PubMed | Google Scholar

  8. Wilson R, Lund V, Sweatman M, Mackay IS, Mitchell DN. Upper respiratory tract involvement in sarcoidosis and its management. Eur Respir J. 1988;1(3):269-272. PubMed | Google Scholar

  9. Zeitlin JF, Tami TA, Baughman R, Winget D. Nasal and sinus manifestations of sarcoidosis. Am J Rhinol. 2000;14(3):157-161. PubMed | Google Scholar

  10. Gulati S, Krossnes B, Olofsson J, Danielsen A. Sinonasal involvement in sarcoidosis: a report of seven cases and review of literature. Eur Arch Otorhinolaryngol. 2012;269(3):891-896. PubMed | Google Scholar

  11. Long CM, Smith TL, Loehrl TA, Komorowski RA, Toohill RJ. Sinonasal disease in patients with sarcoidosis. Am J Rhinol. 2001; 15(3):211-215. PubMed | Google Scholar

  12. Neville E, Mills RG, Jash DK, Mackinnon DM, Carstairs LS, James DG. Sarcoidosis of the upper respiratory tract and its association with lupus pernio. Thorax. 1976;31(6):660-664. PubMed | Google Scholar

  13. Fergie N, Jones NS, Havlat MF. The nasal manifestations of sarcoidosis: a review and report of eight cases. J Laryngol Otol. 1999;113(10):893-898. PubMed | Google Scholar

  14. deShazo RD, O'Brien MM, Justice WK, Pitcock J. Diagnostic criteria for sarcoidosis of the sinuses. J Allergy Clin Immunol. 1999; 103(5 Pt 1):789-795. PubMed | Google Scholar

  15. Kirsten A, Watz H, Kirsten D. Sarcoidosis with involvement of the paranasal sinuses: a retrospective analysis of 12 biopsy-proven cases. BMC Pulmonary Medicine. 2013;13:59. PubMed | Google Scholar

  16. Aubart FC1, Ouayoun M, Brauner M, Attali P, Kambouchner M, Valeyre D, Nunes H. Sinonasal involvement in sarcoidosis: a case-control study of 20 patients. Medicine (Baltimore). 2006 Nov;85(6):365-71. PubMed | Google Scholar

  17. Böttger D. Sarcoidose Theorie und Praxis. Leipzig: Johann Ambrosius Barth. 1982.

  18. Kay DJ, Har-El G. The role of endoscopic sinus surgery in chronic sinonasal sarcoidosis. Am J Rhinol. 2001 Jul-Aug;15(4):249-54. PubMed | Google Scholar

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Original article

Rare involvement of paranasal sinuses in sarcoidosis: case report and literature review

Original article

Rare involvement of paranasal sinuses in sarcoidosis: case report and literature review

Original article

Rare involvement of paranasal sinuses in sarcoidosis: case report and literature review