Original article | Volume 32, Article 136, 22 Mar 2019 | 10.11604/pamj.2019.32.136.18526

Massive splenic calcification in amyloidosis with normal labs and physical exam

Gaurav Dhansukhlal Gheewala, Ifeoma Oriaku

Corresponding author: Gaurav Dhansukhlal Gheewala, Department of Anesthesiology and Critical Care, DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas, USA

Received: 23 Feb 2019 - Accepted: 10 Mar 2019 - Published: 22 Mar 2019

Domain: Cardiology,Intensive care medicine

Keywords: AL amyloidosis, primary amyloidosis, isolated splenic calcification

©Gaurav Dhansukhlal Gheewala et al. Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this article: Gaurav Dhansukhlal Gheewala et al. Massive splenic calcification in amyloidosis with normal labs and physical exam. Pan African Medical Journal. 2019;32:136. [doi: 10.11604/pamj.2019.32.136.18526]

Available online at: https://www.panafrican-med-journal.com/content/article/32/136/full

Home | Volume 32 | Article number 136

Original article

Massive splenic calcification in amyloidosis with normal labs and physical exam

Massive splenic calcification in amyloidosis with normal labs and physical exam

Gaurav Dhansukhlal Gheewala1,&, Ifeoma Oriaku2

 

1Department of Anesthesiology and Critical Care, DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas, USA, 2Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA

 

 

&Corresponding author
Gaurav Dhansukhlal Gheewala, Department of Anesthesiology and Critical Care, DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas, USA

 

 

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A 64-year-old male with medical history of hypertension, type II diabetes, coronary artery disease, and AL amyloidosis involving the heart, kidney and liver was admitted for decompensated heart failure, requiring Intra-Aortic Balloon Pump (IABP) and inotropic support. The patient was listed for heart transplant, but later developed cardiac arrest and required Veno-Arterial Extracorporeal Membrane Oxygenation (VA ECMO) treatment. Abdominal X-ray was obtained to confirm the position of feeding tube which showed massive intra-peritoneal calcification (A). CT abdomen was obtained, and he was found to have extensive splenic calcification measures 8.9 x 7.1cm in cross-section and it spans 8.9 cm in craniocaudal direction (B). Spleen was impalpable on physical exam. Before the cardiac arrest, patient's renal function was at baseline, with the remaining of the basic metabolic panel normal. Hepatic function panel was significant for mild elevation in alkaline phosphatase and alanine aminotransaminases. All other laboratory work including coagulation and iron studies were normal. Nonetheless, patient's condition deteriorated over the course and he expired. Amyloid fibrils have an affinity to calcium and can result in calcific deposition in organs. Literature review showed that in amyloidosis, splenic calcification occurs in conjunction with other organs calcification especially liver. Thus this patient's case highlights the unique presentation of massive splenic calcification without any other organ calcification with relatively normal laboratory and physical examination except findings consistent with his heart failure diagnosis.

 

 

Figure 1: A) abdominal X-ray showing massive intra-peritoneal calcification; B) CT abdomen, showing extensive splenic calcification

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Original article

Massive splenic calcification in amyloidosis with normal labs and physical exam

Original article

Massive splenic calcification in amyloidosis with normal labs and physical exam

Original article

Massive splenic calcification in amyloidosis with normal labs and physical exam

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Key words

AL amyloidosis

Primary amyloidosis

Isolated splenic calcification

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Massive splenic calcification in amyloidosis with normal labs and physical exam