Original article | Volume 26, Article 143, 14 Mar 2017 | 10.11604/pamj.2017.26.143.12047

Rhinocerebral mucormycosis: a rare infection

Moncef Sellami, Malek Mnejja

Corresponding author: Moncef Sellami, Department of Otorhinolaryngology-Head and Neck Surgery Habib Bourguiba University Hospital, Sfax, Tunisia

Received: 19 Feb 2017 - Accepted: 07 Mar 2017 - Published: 14 Mar 2017

Domain: Parasitology,Otolaryngology (ENT)

Keywords: Diabetes mellitus, rhinocerebral mucormycosis, fungal infection

©Moncef Sellami et al. Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this article: Moncef Sellami et al. Rhinocerebral mucormycosis: a rare infection. Pan African Medical Journal. 2017;26:143. [doi: 10.11604/pamj.2017.26.143.12047]

Available online at: https://www.panafrican-med-journal.com/content/article/26/143/full

Home | Volume 26 | Article number 143

Original article

Rhinocerebral mucormycosis: a rare infection

Rhinocerebral mucormycosis: a rare infection

Moncef Sellami 1,2,&, Malek Mnejja1,2

 

1Department of Otorhinolaryngology-Head and Neck Surgery Habib Bourguiba University Hospital, Sfax, Tunisia, 2Sfax Medical School, University of Sfax, Sfax, Tunisia

 

 

&Corresponding author
Moncef Sellami, Department of Otorhinolaryngology-Head and Neck Surgery Habib Bourguiba University Hospital, Sfax, Tunisia

 

 

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Rhinocerebral mucormycosis, also known as zygomycosis, is an acute opportunistic fungal infection with high associated mortality rates. There are some predisposing factors for mucormycosis such as hematological malignancies, severe burns, neutropenia, diabetes mellitus, and the use of corticosteroids. Treatment of rhinocerebral mucormycosis consists of treating the predisposing disease, aggressive surgical debridement and systemic antifungal therapy. We present the case of a 55-year-old diabetic patient treated with insulin who was admitted to the emergency department for a headache and left purulent rhinorrhea for 3 days. The patient was hospitalized for diabetic ketoacidosis, and intravenous insulin infusion therapy and intravenous antibiotherapy were administered. The day after hospitalization the patient developed a ptosis of the left eye associated with edema of the upper eyelid and the left cheek. The nasal endoscopy showed necrotic tissue in the left middle meatus and the middle turbinate associated with profuse purulent discharge. The culture of the nasal swab identified a Rhizopusoryzae and the diagnosis of rhino-cerebral mucormycosis was retained.The patient was put on amphotericin B (1 mg/kg/daily) under medical care in the hospital. The patient underwent a functional endoscopic sinus surgery with debridement of sinuses, ethmoidectomy and left middle meatal antrostomy. Histopathological findings from the biopsy of the maxillary sinus presented aseptate hyphae in necrotic tissue. The outcome was fatal on the third day of hospitalization, despite appropriate reanimation measures.

 

 

Figure 1: (A) clinical examination at the second day of hospitalization found a ptosis of the left eye associated with edema of the left cheek; (B) coronal computed tomography scan showed soft tissue opacification of the left maxillary (arrow) and ethmoid sinuses (star) without orbital involvement

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Original article

Rhinocerebral mucormycosis: a rare infection

Original article

Rhinocerebral mucormycosis: a rare infection

Original article

Rhinocerebral mucormycosis: a rare infection

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Diabetes mellitus

Rhinocerebral mucormycosis

Fungal infection

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