Original article | Volume 24, Article 164, 27 Jun 2016 | 10.11604/pamj.2016.24.164.9908

Generic docetaxel chemotherapy induced skin toxicities in breast cancer patient

Iliass Elalami, Mohamed Ichou

Corresponding author: Iliass Elalami, Departments of Medical Oncology, Military Hospital Med V, Rabat, Morocco

Received: 26 May 2016 - Accepted: 10 Jun 2016 - Published: 27 Jun 2016

Domain: Clinical medicine

Keywords: Generic docetaxel, skin toxicities, breast cancer

©Iliass Elalami et al. Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this article: Iliass Elalami et al. Generic docetaxel chemotherapy induced skin toxicities in breast cancer patient. Pan African Medical Journal. 2016;24:164. [doi: 10.11604/pamj.2016.24.164.9908]

Available online at: https://www.panafrican-med-journal.com/content/article/24/164/full

Home | Volume 24 | Article number 164

Original article

Generic docetaxel chemotherapy induced skin toxicities in breast cancer patient

Generic docetaxel chemotherapy induced skin toxicities in breast cancer patient

Iliass Elalami1,&, Mohamed Ichou1

 

1Departments of Medical Oncology, Military Hospital Med V, Rabat, Morocco

 

 

&Corresponding author
Iliass Elalami, Departments of Medical Oncology, Military Hospital Med V, Rabat, Morocco

 

 

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Female patient, 52 years old, three months after mastectomy due to breast cancer was subjected to chemotherapy with docetaxel. After the first cycle she presented erythema and dysesthesia of the burning sensation type that greatly improved in 2 weeks. After the next session there was relapse of symptoms. She was treated with a topical corticosteroid for 7 days. There was partial improvement of symptoms. At each new chemotherapy session she presented the same symptoms with greater intensity and less expressive improvement with the treatment. Docetaxel belongs to the taxane group and act by inhibiting mitotic activity due to the suppression of microtubule depolymerization. Signs of dermatological toxicity are observed in around 65% of cases and include alopecia, hypersensitivity reactions and ungual alterations. The reactions usually occur after the first treatment cycle and are dose dependent, with relief of discomfort during relapses when the amount of the drug being given is decreased. There usually is spontaneous resolution after 2 weeks, with recurrence when the drug is reintroduced. The use of topical or systemic corticosteroids and application of cold compresses is recommended for incapacitating pain. Preventive treatment with pyridoxine was reported as beneficial in one study. It is recommended to apply local hypothermia to acral regions during medication infusion to decrease local drug perfusion. A few studies suggests that some toxic effects of docetaxel may be related to the excipients used in different formulations of the drug.

 

 

Figure 1: presence of erythema with profound desquamation and skin edema

 

 

 

 

 

 

 

 

Original article

Generic docetaxel chemotherapy induced skin toxicities in breast cancer patient

Original article

Generic docetaxel chemotherapy induced skin toxicities in breast cancer patient

Original article

Generic docetaxel chemotherapy induced skin toxicities in breast cancer patient

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