Original article | Volume 17, Article 296, 18 Apr 2014 | 10.11604/pamj.2014.17.296.3373

Granular Immunofluorescence deposition of IgG in anti-GBM antibody disease

Syed Amer, Mohammed Muqeetadnan

Corresponding author: Syed Amer, Department of Internal Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY -11212, USA

Received: 13 Sep 2013 - Accepted: 24 Nov 2013 - Published: 18 Apr 2014

Domain: Clinical medicine

Keywords: IgG, anti-GBM antibody disease, Immunofluorescence

©Syed Amer et al. Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this article: Syed Amer et al. Granular Immunofluorescence deposition of IgG in anti-GBM antibody disease. Pan African Medical Journal. 2014;17:296. [doi: 10.11604/pamj.2014.17.296.3373]

Available online at: https://www.panafrican-med-journal.com/content/article/17/296/full

Home | Volume 17 | Article number 296

Original article

Granular Immunofluorescence deposition of IgG in anti-GBM antibody disease

Granular Immunofluorescence deposition of IgG in anti-GBM antibody disease

 

Syed Amer1,&, Mohammed Muqeetadnan2

 

1Department of Internal Medicine , Brookdale University Hospital and Medical Center, Brooklyn, NY -11212 , USA/ Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK , 73104, USA

 

 

&Corresponding author
Syed Amer , Department of Internal Medicine , Brookdale University Hospital and Medical Center, Brooklyn, NY -11212 , USA

 

 

Image in medicine

Our patient was a 75 year old male, who presented with worsening dysphagia for solids and liquids and increasing malaise. His past medical history was significant for Chronic Obstructive Pulmonary Disease (COPD), Coronary Artery Disease (CAD) and Peripheral Vascular Disease (PVD). He was then admitted and was found to have a creatinine of 3.5, with an unknown baseline. He was worked up for acute kidney injury and dysphagia. Esophagogastroduodenoscopy (EGD) was done and he was found to have achlasia. Urinalysis was done and it showed showed 3+ proteinuria. Subsequently, his creatinine peaked from 3.5 to 9.9. Serology for Anti-neutrophil cytoplasmic antibody (ANCA) was negative, but Anti-glomerular basement membrane antibody (anti-GBM Ab) was positive, with a titer of 184. Renal biopsy done,which was consistent with granular GBM than the usual linear pattern. He was subsequently started on stress dose of steroids. He did not show any response to steroids and so he was also started on cyclophosphamide and plasmapheresis was also done. Unfortunately, he did not respond to any of these therapies. He started deteriorating and soon developed shortness of breath, hemoptysis and diffuse alveolar hemorrhage. He was then admitted in the intensive care unit (ICU) and the decision was made to start dialysis, cyclophosphamide was stopped and the steroids were slowly tapered.The patient gradually improved with dialysis. This case demonstrates a very rare pattern of immunofluorescence in a patient with anti-GBM antibody disease. Normally, the immunofluorescence microscopy in these patients shows characteristic linear deposition of IgG. But our patient had a granular immunofluorescence pattern, a very rare finding in a patient with Goodpasture's disease. To our knowledge this is the first reported case with such an immunofluorescence pattern in a patient with Goodpasture's disease in the entire medical literature.

Figure 1: Granular pattern of IgG deposition seen. Usually a linear deposition of the antibodies is seen

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Original article

Granular Immunofluorescence deposition of IgG in anti-GBM antibody disease

Original article

Granular Immunofluorescence deposition of IgG in anti-GBM antibody disease

Original article

Granular Immunofluorescence deposition of IgG in anti-GBM antibody disease

Volume 37 (Sep - Dec 2020)
This article authors
On Pubmed
On Google Scholar
Citation [Download]
EndNote
Reference Manager
Zotero
BibTex
ProCite

Navigate this article
Key words

IgG

Anti-GBM antibody disease

Immunofluorescence

Article metrics
PlumX Metrics
Granular Immunofluorescence deposition of IgG in anti-GBM antibody disease