Rhabdomyosarcoma: a rapidly growing malignancy

Prashanth Panta, David Felix

PAMJ. 2015; 22:121. Published 12 Oct 2015 | doi:10.11604/pamj.2015.22.121.7479

An 8 year old boy presented with a swelling on the left side of the face (A). On inquiry, he revealed that it had been rapidly growing since he first noticed 15 days earlier, and was associated with sharp pain at night. He had constitutional symptoms such as weight loss and fatigue, but no history of fever. On examination, the swelling had a shiny appearance, with no changes in skin color and the mouth opening was partly restricted. There was no local rise of temperature. The left submandibular lymphnodes were palpable, non-tender and fixed. Intraorally, there was a large nodule (B) measuring 5x3 cms, in the lower left buccal sulcus. The nodule was red in color, covered by necrotic slough, and showed areas of bleeding. It was tender, indurated and fixed to the underlying structures. The differential diagnosis included Burkitt's lymphoma, rhabdomyosarcoma, Ewing's sarcoma. On radiographic examination, there were no cystic areas, and bony erosions with respect to the mandible. An incisional biopsy was performed and the microscopic features suggested "Rhabdomyosarcoma-Embryonic type". The patient was treated with chemotherapy (vincristine, actinomycin-D, cyclophosphamide) plus radiotherapy (5200cGy for 8weeks). No recurrence has occurred during a six month follow up period, and he is still under long term review. Rhabdomyosarcoma is a rapidly growing, childhood malignancy of striated muscle, that exhibits some male predilection. Rhabdomyosarcoma of the oral cavity accounts for 10-15% of all the head and neck cases; the most common sites are tongue, palate and buccal mucosa.
Corresponding author
Prashanth Panta, Department of Oral Medicine and Radiology, MNR Dental College and Hospital, Narsapur road, Sangareddy(502294), Medak District, Telangana, India (maithreya.prashanth@gmail.com)


The Pan African Medical Journal (ISSN: 1937-8688) is a subsidiary of the Pan African Medical Journal. The contents of this journal is intended exclusively for professionals in the medical, paramedical and public health and other health sectors.

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