Indometacin induced corneal perforation in a patient with rheumatoid arthritis
Fouad Chraibi, Idriss Andaloussi Benatiya
Corresponding author: Fouad Chraibi, Unniversity Allal Ben Abdellah, University Hospital Hassan II, Fez, Morocco 
Received: 18 Apr 2016 - Accepted: 15 May 2016 - Published: 08 Jan 2018
Domain: Clinical medicine
Keywords: Corneal perforation, indometacin, rheumatoid arthritis
©Fouad Chraibi et al. Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cite this article: Fouad Chraibi et al. Indometacin induced corneal perforation in a patient with rheumatoid arthritis. Pan African Medical Journal. 2018;29:16. [doi: 10.11604/pamj.2018.29.16.9649]
Available online at: https://www.panafrican-med-journal.com/content/article/29/16/full
Original article 
Indometacin induced corneal perforation in a patient with rheumatoid arthritis
Indometacin induced corneal perforation in a patient with rheumatoid arthritis
Fouad Chraibi1,&, Idriss Andaloussi Benatiya1
1University Allal Ben Abdellah, University Hospital Hassan II, Fez, Morocco
&Corresponding author
Fouad Chraibi, University Allal Ben Abdellah, University Hospital Hassan II,
Fez, Morocco
Severe corneal complications associated with the use of anti inflammatory drugs (NSAID) eye drops are known. We report the case of a patient of 57 years treated for rheumatoid arthritis with a central corneal perforation of the right eye following the use of indomethacin eye drops in the postoperative period following cataract surgery. The image shows a paracentral corneal perforation with iris prolaps. The course was favorable with improvement in visual acuity and complete healing of the corneal perforation after stoping indometacin and using of bandage contact lens. The anti inflammatory drugs should be avoided in cases of rheumatoid arthritis because they increase the risk of perforation. Indomethacin, like other molecules in the same therapeutic class should be used with caution in patients with general risk factors of suffering from ocular surface.
Figure 1: paracentral corneal perforation
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