Laugier-Hunziker syndrome
Amir Feily, Reza Sahraei
The Pan African Medical Journal. 2016;23:54. doi:10.11604/pamj.2016.23.54.9035

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Laugier-Hunziker syndrome

Cite this: The Pan African Medical Journal. 2016;23:54. doi:10.11604/pamj.2016.23.54.9035

Received: 04/02/2016 - Accepted: 06/02/2016 - Published: 29/02/2016

Key words: Lip hyperpigmentation, longitudinal melanonychia, systemic symptoms

© Amir Feily et al. The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Available online at: http://www.panafrican-med-journal.com/content/article/23/54/full

Corresponding author: Amir Feily, Department of Dermatology, Jahrom University of Medical Sciences, Jahrom, Iran (dr.feily@yahoo.com)


Laugier-Hunziker syndrome

Amir Feily1,&, Reza Sahraei1

 

1Department of Dermatology, Jahrom University of Medical Sciences, Jahrom, Iran, 2Department of Anesthesiology , Jahrom University of Medical Sciences, Jahrom, Iran

 

 

&Corresponding author
Amir Feily, Department of Dermatology, Jahrom University of Medical Sciences, Jahrom, Iran

 

 

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A healthy 37-year-old woman presented to the clinic with a 1-year history of progressive asymptomatic hyperpigmented macules on the lips and longitudinal hyperpigmentation of the left thumb extending to the cuticle. There was no relevant drug or positive family history or evidence of other pigmented lesions. On examination, there was linear, brownish, reticular pattern on both inner aspect of her lips and longitudinal melanonychia in the left thumb extending to the cuticle on the middle aspect of the nail. Laboratory tests, Chest X-ray and abdominal ultrasound were normal. Colonoscopic findings were negative for any gastrointestinal pathology or tumorous formations associated with oral hyperpigmentations. Based on the endocrinologist's exam adrenal insufficiency was ruled out and histological examination of the lip lesions revealed non-specific changes such as acantosis and hyperpigmentation of the basal layer. By excluding the other differentials, diagnosis of Laugier-Hunziker syndrome was made. Laugier-Hunziker syndrome is a benign chronic progressive asymptomatic hyperpigmented macules on the lips and buccal mucosa and often is associated with longitudinal melanonychia (A). The main differential diagnoses are drug induced hyperpigmentation, racial pigmentation, smokerís melanosis, Addisons disease and Peutz-Jeghers syndrome (B). As a diagnosis of exclusion Laugier-Hunziker syndrome always should be considered in the differential diagnosis of patients with mucocutaneous and nail hyperpigmentation without any systemic symptoms, specially in the middle-aged groups (A,B). Therefore, its diagnosis can easily exclude other severe pigmentary disorders and avoid unnecessary diagnostic procedures. Treatment is not necessary exept for cosmetic purposes (B).

 

 

Figure 1: A) linear, brownish, reticular pattern on both inner aspects of the lips; B) longitudinal melanonychia in the left thumb extending to the cuticle on the middle aspect of the nail

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


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