Unusual presentation of rare primary lymphoma of bone
Malala Razakanaivo, Nomeharisoa Rodrigue Emile Hasiniatsy
The Pan African Medical Journal. 2015;22:317. doi:10.11604/pamj.2015.22.317.8232

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Images in medicine

Unusual presentation of rare primary lymphoma of bone

Cite this: The Pan African Medical Journal. 2015;22:317. doi:10.11604/pamj.2015.22.317.8232

Received: 20/10/2015 - Accepted: 12/11/2015 - Published: 02/12/2015

Key words: Bone, lymphoma, imaging

© Malala Razakanaivo et al. The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Available online at: http://www.panafrican-med-journal.com/content/article/22/317/full

Corresponding author: Malala Razakanaivo, Oncology Unit, University Hospital of Antananarivo, Hôpital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar (malalarazaka@yahoo.fr)


Unusual presentation of rare primary lymphoma of bone

 

Malala Razakanaivo1,&, Nomeharisoa Rodrigue Emile Hasiniatsy2

 

1Oncology Unit, University Hospital of Antananarivo, Hôpital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar, 2Medical Oncology Unit, Centre Hospitalier de Soavinandriana, Antananarivo, Madagascar

 

 

&Corresponding author
Malala Razakanaivo, Oncology Unit, University Hospital of Antananarivo, Hôpital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar

 

 

Image in medicine

Primary bone lymphoma is a distinct disease. It represents only 3% of all malignant bone tumours and less than 1% of non-Hodgkin's lymphoma. It is essential to differentiate it from other tumours because of its good prognosis. We report a case of 45 years old male who presented one year ago with a painful left arm. His symptoms started after minimal trauma. The pain persisted for 6 months and became severe. It was managed by traditional medicine a practitioners who diagnosed it as a shoulder's sprain and did several massages sessions. The patient had worsening of his pain. On physical examination, shoulder movements were painful. Left arm was entirely swell. Superficial lymph nodes were not enlarged. The X-ray radiograph of the left upper extremity showed a fracture of the proximal humerus and large condensation lesion of the all humerus. Patient was posted for an open biopsy which revealed a primary diffuse large B cell lymphoma. Flow cytometric immunophenotyping showed positivity for CD10, CD20 and BCL6 and negativity for CD5, MUM1 and BCL2. Bone marrow and cerebrospinal examinations were normal. Contrast enhanced computed tomography of chest and abdomen failed to show evidence of any lymphomatous deposits. The patient was treated with chemotherapy including cyclophosphamide, doxorubicin, vincristine, and prednisolone with a good clinical response. He has been lost to follow up after five cycles of chemotherapy because of financial problem. The diagnostic study should begin with simple X-ray but adequate biopsies for histologic examination remain the standard in diagnosis.

 

 

Figure 1: unusual presentation of rare primary lymphoma of bone

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


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