The managed hypertensive: the costs of blood pressure control in a Nigerian town
Olayinka Stephen Ilesanmi, Olusimbo Kehinde Ige, Akindele Olupelumi Adebiyi
The Pan African Medical Journal. 2012;12:96. doi:10.11604/pamj.2012.12.96.1209

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The managed hypertensive: the costs of blood pressure control in a Nigerian town

Cite this: The Pan African Medical Journal. 2012;12:96. doi:10.11604/pamj.2012.12.96.1209

Received: 10/09/2011 - Accepted: 26/05/2012 - Published: 06/08/2012

Key words: Hypertensive, management, financial, cost, time, burden, Nigeria, therapy, patients, drugs, resources

© Olayinka Stephen Ilesanmi et al. The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Corresponding author: Olayinka Stephen Ilesanmi, Department of Community Medicine, University College Hospital, Ibadan, Nigerian (

The managed hypertensive: the costs of blood pressure control in a Nigerian town


Olayinka Stephen Ilesanmi1,&, Olusimbo Kehinde Ige1, Akindele Olupelumi Adebiyi1,2


1Department of Community Medicine, University College Hospital, Ibadan, Nigeria, 2Department of Preventive Medicine and Primary Care, Faculty of Public Health College of Medicine, University of Ibadan, Ibadan, Nigeria



&Corresponding author
Olayinka Stephen Ilesanmi, Department of Community Medicine, University College Hospital, Ibadan, Nigerian




Hypertension is the number one risk factor for cardiovascular disease in sub-Saharan Africa and thus has emerged as a major public health concern [1]. In addition to the large health burden, there is an enormous financial burden associated with the disease [2]. This is because the treatment of hypertension requires an investment over many years to ensure disease-free years among those affected. The economic consequences of this long term therapy often limit the ideals of pharmacologic blood pressure control in many developing countries including Nigeria [2].


In addition to the direct costs in form of treatment related costs there are also indirect costs related to lost man hours and savings among workers due to catastrophic healthcare expenditures. In Nigeria these costs are borne almost entirely by the individuals as the health care financing is still mostly from out of pocket payments [3]. In limited resource settings where chronic disease control is yet to be prioritised and access to health care is limited, cost effective and affordable approaches are needed to meet this challenge [4]. Unfortunately, the number of studies that report these costs is quite small, as few economic analyses relating to management of chronic diseases have been conducted in Nigeria. In addition the health systems designed to cater for patients with chronic illnesses like hypertension have not fully evaluated the burden of long term therapy and its effect on patient outcome. This study therefore assessed the cost of anti-hypertensives, the cost effectiveness of treatment regimens and patient outcomes among rural patients in Southwest Nigeria. Findings would be useful in designing strategies to limit the long-term financial burden on both hypertensive patients and the health system.




This was a cross sectional survey of 250 rural patients with primary hypertension attending the General hospital at Igbo-Ora a semi-urban community in Oyo State, South West Nigeria. All patients were from Idere a small town located about 3.5 kilometres from the hospital. Idere is a small town in Ibarapa central Local Government Area of Oyo state. Its local government headquarter is Igboora, which lies about 80 km away from Ibadan, the state capital. It is situated in the rain forest belt of the country. Majority of the residents are the native Yorubas. The main occupations are farming and trading. Social infrastructure available include electricity, mobile telecommunications, several manually operated boreholes, tarred road network, primary health care centres, primary and secondary school [5]. The study involved the chart review of all patients from Idere who had been seen at the hospital over a ten year period (2001-2010). All patients made out of pocket payments for health services and drugs. All prescribed drugs were generic.




Stage of hypertension at diagnosis was according to the JNC 7 classification [6]. Patients with systolic blood pressure of 140–159 mmHg or diastolic 90–99 mmHg were classified as stage 1 while patients with systolic blood pressure of ≥ 160 mmHg or diastolic ≥ 100mm Hg were classified as having stage 2 hypertension The primary outcomes used was the achievement rates of target blood pressure (i.e BP < 140/90 mmHg or < 130/80 mm Hg for diabetics). Persistence with therapy according to the International Society for Pharmacoeconomics & Outcomes research was defined as the continuing use in time of the prescribed therapy [7]. This was recorded as documented from patient’s history in the case records.


Cost Analysis


The direct cost examined was limited to the cost of antihypertensive medication. Cost was calculated as a function of the dosage prescribed and the prices in the hospital or community pharmacies as of September, 2010. The monthly cost of a 30-day antihypertensive supply based on the recommended daily dose was computed. Indirect costs were the cost of transportation to the hospital. The total cost was the sum of the both the direct and indirect costs.


Mono-therapy was defined as use of a single medication containing only one antihypertensive agent. Combination drug therapy was defined as use of multiple antihypertensive agents.


Cost-effectiveness ratios [8] were estimated as the average treatment cost per patient reaching the target blood pressure. The cost-effectiveness relationship was calculated as the ratio of the monthly mean cost to the proportion of patients with controlled HBP, for each pharmacological group of drugs prescribed. The CER was adjusted for hypertension staging at diagnosis.


A relative CER was also described for each drug group, using the CER of the most cost-effective therapy as denominator (i.e. relative CER=CER of therapy/CER of most cost-effective therapy in the study) [2] CER=mean monthly cost /% patients with controlled Blood Pressure, RCER=CER/CER of most cost effective drug.


Data Analysis: mean costs were compared with the student t test at a level of significance of 5%.




The mean age of patients was 61±11.2 years. More than half 167(66.8%) were 60 years and above and 148 (59.2%) were females. Many of the patients were traders 142(56.8%). The mean household income was ₦14,300 ± ₦2, 940($95.3±$19.6). (Table 1).


Clinical profile of patients


The majority of patients had Stage 2 hypertension had diagnosis and 39(15.6%) had other chronic illnesses other than hypertension (Table 2)


Prescribed antihypertensive regimen


The number of drugs prescribed ranged from 1-4 (median 2). Only 32(12.8%) had monotherapy, 157(62.8%) had two drugs, 58(23.2%) three drugs and 3(1.2%) four drugs prescribed. The median duration of treatment was 12 months (range 1- 91months). The classes of anti-hypertensives commonly prescribed are shown in Figure 1. Diuretics and Alpha methyl dopa (centrally acting) were the most often prescribed anti-hypertensive.


Direct monthly cost of treatment and cost effectiveness


Table 3 shows the monthly costs and the cost effectiveness of the frequently prescribed drugs. The median monthly cost of drugs was ₦900 (range ₦300 - ₦3,000) $6(range$2-$20). The most cost-effective drug was Methyl Dopa with an average monthly cost of ₦800 ($5.3), and CER of 8. Two drug therapies were more cost effective than three drug regimens. Table 4 shows the transportation costs. The round fare to the hospital was ₦120. Close to half were given monthly appointment 114 (45.6%).


Total cost implication of treatment


The mean total cost of treatment was ₦1440±560 ($9.6±3.7), the mean proportion of the household income spent on treatment was 11.1% ± 4.2%, 132(52.8%) spent greater than 10% of their total household income on treatment.


Treatment outcome


Less than half (47.6%) were persistent with prescribed drugs and appointments (55.2%- mono-therapy and 45.9%- combination therapy (p=0.34)). Successful BP control was recorded in 33.6% overall (48.3% -mono-therapy and 32.1%-combination therapy; p=0.084).


Comparison of mean treatment costs


The mean total cost of treatment was significantly higher for those who had co-morbities, higher BP at diagnosis and those on 3 or 4 drug regimens. Higher mean cost was also significantly associated with a higher percentage of the total household income being spent (P<0.05). The mean cost of treatment did not vary significantly by age, sex or income of the patients. The mean cost was not significantly associated with adherence with prescribed treatment (Table 5).




This study evaluated treatment cost for rural patients with hypertension and the cost effectiveness of prescribed antihypertensive treatment. Many patients were prescribed two or more drugs with diuretics and centrally acting drugs being the most commonly prescribed drugs. Although alpha-Methyl Dopa is not included in recent treatment guidelines for managing hypertension at the community level in Sub Saharan Africa [9] it continues to be prominent in the treatment regimen of hypertension as documented in other African surveys [10-12]. This is probably due to the low cost and observed effectiveness. Even though the number of patients on a-Methyl Dope as mono therapy was small in comparison to other drug types, it emerged as the most cost effective drug in this cohort of patients. The standardized monthly cost of antihypertensive drug therapy was lower for diuretics in comparison with any other drug. Similar low costs relating to diuretics have been described in other studies [13-15]. Diuretics as fixed dose combinations (FDC) of Hydrochlorothiazide and Amiloride also emerged as one of the most cost effective treatment option, replicating other findings [16]. Guidelines for Sub-Saharan Africa have also re-affirmed the efficacy of diuretics and diuretic-based combinations over other classes of antihypertensive drugs [17]. The CER for FDC diuretic of 12.8 was much lower than the 42.9 reported in another Nigerian study conducted in a tertiary hospital in an urban setting [10]. The observed differences CER might be attributable to the different study settings.


Persistence with drug therapy among this rural population was 47.6% much lower than the 82.5% previously documented among urban patients in Nigeria [2]. Even though those on mono-therapy were more often persistent with therapy this was not significantly so. This varies from the findings of other African studies in which cost appeared as a major factor in compliance with treatment among hypertensive patients [18-19]. The rates of blood pressure control was also low, only about a third of patients achieved the target BP, higher control rates were observed for patients on mono-therapy as shown by previous studies [2, 20]. Some population studies have also reported hypertension control rates as low as 53.1% for the US, 41.0% for Canada, 33.6% for Germany and 29.2% for the UK [21].


The economic burden of hypertension treatment was significant, about half of the patient were spending a tenth or more of their income on health care related expenses. The mean cost of treatment was significantly higher for those who had co-morbidities, higher BP at diagnosis and those on 3 or 4 drug regimens. Similar relations showing a higher total cost for patients with co-morbid conditions and patients on combination therapy have been observed in another work [22]. It seems patients with higher risk also bear the heaviest financial burden. The utilization of cheaper yet equally effective diuretics based drug combinations may thus be most beneficial.




Thiazide diuretics are still the backbone of hypertension treatment especially in low resource settings even as mono-therapy. Hypertensive management therefore requires a response adapted to the local context. Proven solutions are needed to optimize the application of treatment guidelines in less developed societies with limited resources and to explore cost reduction strategies in the management of hypertensive in a poor resource setting. Alpha Methyl Dopa is a useful drug in the management of Hypertension though it was not included in the guideline. The cost of health care is probably underestimated as other health care related costs such as those for laboratory tests and hospital admissions could not be ascertained. In assessing cost effectiveness of antihypertensive the influence of patients’ compliance and persistence with treatment were not considered. Another limitation is the small number of patients on other combinations of antihypertensive apart from those listed which precluded them from analysis, larger numbers might have allowed for more valid comparison. Inspite of these limitations the study provides useful data on individual expenditure on hypertension treatment in Nigeria.




The authors thank the staff of Health Records Department of General Hospital, Igbo-Ora, Oyo State for their role in the collection of data.



Competing interests

The authors declare that they have no competing interests.



Authors’ contributions

Olayinka Stephen Ilesanmi: conception and design, analysis of data, interpretation of data and drafting of the manuscript and revision of the version of the manuscript to be published. Olusimbo Kehinde Ige: conception and design, analysis of data, interpretation of data, and revision of the version of the manuscript to be published. Akindele Olupelumi Adebiyi: Conception and design, revising the article critically for important intellectual content, and revision of the version of the manuscript to be published. All the authors have read and approve the final version of the manuscript.



Tables and figures

Table 1: Socio-demographic characteristics of patients

Table 2: Clinical profile of patients

Table 3: Adjusted Cost effectiveness of common Anti hypertensive therapy

Table 4: In-direct costs (transportation cost)

Table 5: Comparison of mean treatment costs

Figure 1: Prescribed Anti-hypertensive




  1. Gaziano TA. Economic burden and the cost-effectiveness of treatment of cardiovascular diseases in Africa. Heart. 2008 Feb;94(2):140-4. This article on PubMed

  2. Amira CO, Okubadejo NU. Antihypertensive pharmacotherapy in a developing economy: pattern, acquisition costs and conformity to international guidelines in a tertiary-care setting. J Hum Hypertens. 2006 Nov;20(11):894-7. This article on PubMed

  3. Obikeze OO, Ige OK, Osungbade KO, Olumide EA, Asuzu MC. An overview of the National Health Insurance Scheme in Nigeria. Dokita. 2010;1:15-21

  4. Kadiri S. Tackling cardiovascular disease in Africa. BMJ. 2005;331:711-2. This article on PubMed

  5. Omoniyi A Olawale, Owoaje ET. Incidence and pattern of injuries among residents of a rural area in South-Western Nigeria: a community-based study. BMC Public Health. 2007;7:246. This article on PubMed

  6. Chobanian AV, Bakris GL, Black HR, Cushman WC, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003 May 21;289(19):2560-72. This article on PubMed

  7. ISPOR. Accomplishments. ISPOR Medication Compliance And Persistence Special Interest Group (MCP).
    Available at: Accessed 21 June 2011

  8. Kucerová M, Straková M, Polívková Z. The Prader-Willi syndrome with a 15/3 translocation. J Med Genet. 1979 Jun;16(3):234-5. This article on PubMed

  9. Twagirumukiza M, Bortel LMV. Management of hypertension at the community level in Sub-Saharan Africa (SSA): towards a rational use of available resources. Journal of Human Hypertension. 2011;25:47-56. This article on PubMed

  10. Yusuff KB, Balogun OB. Pattern of drug utilization among hypertensives in a Nigerian teaching hospital. Pharmacoepidemiol Drug Saf. 2005 Jan;14(1):69-74. This article on PubMed

  11. Edwards PR, Lunt DW, Fehrsen GS, Lombard CJ, Steyn K. Improving cost-effectiveness of hypertension management at a community health centre. S Afr Med J. 1998;88(5):549-54. This article on PubMed

  12. Pillay T, Smith AJ, Hill SR. A comparison of two methods for measuring anti-hypertensive drug use: concordance of use with South African standard treatment guidelines. Bull World Health Organ. 2009;87(6):466-71. This article on PubMed

  13. Ambrosioni E. Pharmacoeconomics of hypertension management: the place of combination therapy. Pharmacoeconomics. 2001;19:337-47. This article on PubMed

  14. Degli-Esposti L, Di Martino M, Saragoni S, Sgreccia A, Capone A, Buda S, Degli-Esposti E. Pharmacoeconomics of antihypertensive drug treatment: an analysis of how long patients remain on various antihypertensive therapies. J Clin Hypertens(Greenwich). 2004;6(2):76-84. This article on PubMed

  15. Dias da Costa JS, Fuchs SC, Olinto MT, Gigante DP, Menezes AM, al MSe. Cost effectiveness of hypertension treatment: a population based study. Sao Paulo Med J. 2002;120:100-4. This article on PubMed

  16. Appel L. The verdict from ALLHAT - thiazide diuretics are the preferred initial therapy for hypertension. JAMA. 2002;288:3039-42. This article on PubMed

  17. Seedat YK, Croasdale MA, Milne FJ, et al. South African hypertension guideline 2006. S Afr Med J. 2006 Apr;96(4 Pt 2):337-62. This article on PubMed

  18. Ohene Buabeng K, Matowe L, Plange-Rhule J. Unaffordable drug prices: the major cause of non-compliance with hypertension medication in Ghana. J Pharm Pharm Sci. 2004;7(3):350-2. This article on PubMed

  19. Konin C, Adoh M, Coulibaly I, Kramoh E, Safou M, N'Guetta R, N'Djessan JJ, Koffi J. Black Africans' compliance to antihypertensive treatment. Arch Mal Coeur Vaiss. 2007;100(8):630-4. This article on PubMed

  20. Adigun AQ, Ishola DA, Akintomide AO, Ajayi AAL. Shifting trends in the pharmacologic treatment of hypertension in a Nigerian tertiary hospital: a real-world evaluation of the efficacy, rationality and pharmaco-economics of old and newer antihypertensive drugs. J Hum Hypertens. 2003;17:277-85. This article on PubMed

  21. Sharma A, Wittchen H, Kirch W, Pittrow D, Ritz E, Goke B, Lehnert H, Tschope D, Krause P, Hofler M, et al. High prevalence and poor control of hypertension in primary care: cross-sectional study. J Hypertens. 2004;22(3):479-86. This article on PubMed

  22. Degli- Esposti E, Sturani A, Degli-Esposti L, Macini P, Falasca P, Valpiani G, Buda S. Pharmacoutilization of antihypertensive drugs: a model of analysis. Int J Clin Pharmacol Ther. 2001;39(6):251-8. This article on PubMed

  23. Ige OK, Nwachukwu CC. Areas of dissatisfaction with primary health care services in government owned health facilities in a semi urban community in Nigeria. Journal of Rural and Tropical Public Health. 2010; 9:19-23



















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