Thoracic extramedullary hematopoiesis

Ashwin Karnan, Anjana Ledwani

PAMJ. 2024; 47:132. Published 22 Mar 2024 | doi:10.11604/pamj.2024.47.132.43083

A 22-year-old male presented to the outpatient department with complaints of fever, cough with expectoration, and breathlessness for the past 8 days. The patient is a known case of thalassaemia major with a history of splenectomy 10 years back. Chest X-ray showed bilateral homogenous shadows with suspicion of eosinophilic pneumonia, septic emboli, or metastases to the lung. Computed tomography of the thorax showed multiple well-defined para-osseous soft tissue density masses suggestive of thoracic extramedullary hematopoiesis. Chronic anemia may lead to extramedullary hematopoiesis due to failure of erythropoiesis in the bone marrow. Etiology includes myeloproliferative disorders and hemoglobinopathies. These masses are usually hypervascular and fine needle aspiration is preferred over biopsy. Treatment modalities include excision, radiotherapy, and repeated blood transfusion to decrease extramedullary hematopoiesis.
Corresponding author
Ashwin Karnan, Department of Respiratory Medicine, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, India (ashwin2700@gmail.com)


The Pan African Medical Journal (ISSN: 1937-8688) is a subsidiary of the Pan African Medical Journal. The contents of this journal is intended exclusively for professionals in the medical, paramedical and public health and other health sectors.

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