Table 4: examples of advantages and inconveniences that may influence the choice of molecules most often used in painful neuropathy
INN	Trade name	Advantages	Inconveniences
Gabapentin	Neurontin* or generic	No major drug interactions	Side effects Titration. Cost 3 times a day formulation
Duloxetin	Cymbalta*	Simple and fast titration Once daily formulation Anxiolytic and antidepressant effect	Side effects Drugs interactions
Pregabalin	Lyrica*	No major drugs interactions Anxiolytic effect	Side effects Titration. Cost
Amytriptiline Imipramine Clomipramine	Laroxyl* Tofranil* Anafranil*	Drops Cost Anxiolytic effect (clomipramine) High antidepressant effect if high dose	Titration Anticholinergic and adrenal effects
Oxycodone slow-release Morphine	Oxycontin LP*	Effect on possible inflammatory pain associated	Side effects Addiction
Tramadol		Effect on possible inflammatory pain associated	Side effects Addiction
Carbamazepin	Tegrétol*		Titration: cost Enzyme inducer Side effects
Clonazépam	Rivotril*	Drops Cost	Analgesic effect not studied. Drowsiness, Memory problems Addiction, Withdrawal syndrome
INN = International Nonproprietary Name