Table 3: summary of findings table for micronutrients versus placebo in HIV-infected and -exposed children with diarrhoea
Patient or population: HIV-infected and HIV-exposed children with diarrhoea Settings: Tertiary referral centre in a peri-urban area of South Africa Intervention: Micronutrients versus placebo
Outcomes	Illustrative comparative risks^+ (95% CI)		Relative effect (95% CI)	No of Participants (studies)	Certainty of the evidence (GRADE)	Comments
	Assumed risk	Corresponding risk
	Placebo	Micronutrients
Clinical cure	See comment	See comment	Not estimable	N/A	See comment	Not measured
All-cause mortality: Assessed by clinician at study site	See comment	See comment	Not estimable	50 (1 study)	⊕⊕⊝⊝ low^1	N/A
Hospitalisation due to diarrhoea: Measured by medical staff as time to cessation of diarrhoea	See comment	See comment	Not estimable	44 (1 study)	⊕⊕⊝⊝ low^1	N/A
^+The basis for the assumed risk is the control group risk across the included studies. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). ^1Downgraded by two points for imprecision: only one small study reported on this outcome
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate Very low quality: We are very uncertain about the estimate