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Table 1: CDC Panel for interpretation of Hepatitis B serology results |
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|
HBsAg |
Anti-HBs IgG |
Anti-HBc IgG |
Anti-HBc IgM |
Interpretation |
|
Negative |
Negative |
Negative |
Negative |
Susceptible |
|
Negative |
Positive |
Negative |
Negative |
Immune due to hepatitis B vaccination |
|
Negative |
Positive |
Positive |
Negative |
Immune due to natural infection |
|
Positive |
Negative |
Positive |
Positive |
Acutely infected |
|
Positive |
Negative |
Positive |
Negative |
Chronically infected |
|
Positive |
Positive |
Positive |
Negative |
Chronic carrier |
|
Positive |
Positive |
Negative |
Negative |
Chronic carrier with possible false negative anti HBc test |
|
Positive |
Negative |
Negative |
Negative |
Chronic carrier with possible false negative anti HBc test |
|
Negative |
Negative |
Positive |
Negative |
Indeterminate: Four interpretations possible: Maybe recovering from an acute HBV infection Distantly immune and test not sensitive enough to detect very low levels of anti-HBs in serum Carrier with undetectable level of HbsAg Susceptible with false positive anti-HBc |
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Source: CDC- Viral Hepatitis B. Interpretation of the hepatitis B panel. |
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