Table 1: CDC Panel for interpretation of Hepatitis B serology results

HBsAg

Anti-HBs

IgG

Anti-HBc IgG

Anti-HBc IgM

Interpretation

Negative

Negative

Negative

Negative

Susceptible

Negative

Positive

Negative

Negative

Immune due to hepatitis B vaccination

Negative

Positive

Positive

Negative

Immune due to natural infection

Positive

Negative

Positive

Positive

Acutely infected

Positive

Negative

Positive

Negative

Chronically infected

Positive

Positive

Positive

Negative

Chronic carrier

Positive

Positive

Negative

Negative

Chronic carrier with possible false negative anti HBc test

Positive

Negative

Negative

Negative

Chronic carrier with possible false negative anti HBc test

Negative

Negative

Positive

Negative

 Indeterminate: Four interpretations possible:

Maybe recovering from an acute HBV infection

Distantly immune and test not sensitive enough to detect very low levels of anti-HBs in serum

Carrier with undetectable level of HbsAg

Susceptible with false positive anti-HBc

Source: CDC- Viral Hepatitis B. Interpretation of the hepatitis B panel.