Research - Abstract

Cite this article:

Mona M Rashed, Alemayehu Bekele. The Prevalence and pattern of HPV-16 immunostaining in uterine cervical carcinomas in Ethiopian women: a pilot study.
The Pan African Medical Journal. 2011;8:21

Key words: Cancer cervix, HPV16, immunohistochemistry, Ethiopia

Permanent link: http://www.panafrican-med-journal.com/content/article/8/21/full

Received: 29/12/2010 - Accepted: 06/03/2011 - Published: 11/03/2011

© Mona M Rashed et al. The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The Prevalence and pattern of HPV-16 immunostaining in uterine cervical carcinomas in Ethiopian women: a pilot study

Mona M Rashed^1,&, Alemayehu Bekele²

¹Department of Pathology, Affiliated to General Organization of Teaching Hospitals and Institutes, Egypt, ²Department of Pathology, Affiliated to Jimma University, Ethiopia

^&Corresponding author
Mona M. Rashed, Department of Pathology, Affiliated to General Organization of Teaching Hospitals and Institutes, Egypt

Introduction

Cancer of the cervix uteri is the second most common cancer among women worldwide. The association of human papillomavirus (HPV) infection with cervical carcinogenesis is well documented. This is a pilot study aiming to studying the prevalence and the pattern of Human Papilloma Virus Type 16 (HPV16) by immunostaining in the tissues of cervical carcinomas of Ethiopian women.

Methods

20 specimens of uterine cervical carcinomas were studied histopathologically and immunohistochemically for HPV16.

Results

Histologically the specimens were classified as: Ten cases were Non Keratinized Squamous cell carcinoma (NKSCC), six cases were Keratinized Squamous Cell Carcinoma (KSCC) and four cases were Adenocarcinoma (ADC). Immunohistochemistry study showed positivity in eleven cases (55%); seven cases (35%) were non-keratinized squamous cell carcinoma; three cases (15%) were keratinized squamous cell carcinoma and one case (5%) belonged to the adenocarcinomas.

Conclusion

This study reveals a significant detection of HPV in Ethiopian women by the use of advanced techniques such as Immunohistochemistry (IHC). The data of this study suggested that the marked expression of the HPV 16 was in the less differentiated uterine cervix carcinomas.

In Google Scholar

In PubMed