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Cite this article:
Mona Mohamed Rashed, Alemayehu Bekele. Neuroendocrine differentiation in a case of cervical cancer. The Pan African Medical Journal. 2010;6:4 Key words: Cervical cancer, cervix, chromogranine A, small cell carcinoma Permanent link: http://www.panafrican-med-journal.com/content/article/6/4/full Received: 11/06/2010 - Accepted: 18/07/2010 - Published: 28/07/2010 © Mona Mohamed Rashed et al. The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Neuroendocrine differentiation in a case of cervical cancer
Mona Mohamed Rashed1, Alemayehu Bekele2
1Department of Pathology, General Organization of Teaching Hospitals and Institutes, Egypt, 2Department of Pathology, Jimma University, Ethiopia
&Corresponding author
Mona M. Rashed, MD, Department of Pathology, Damanhour National Medical Institute, affiliated to the: General Organization of Teaching Hospitals and Institutes, Egypt
Abstract
Neuroendocrine neoplasms may occur in the uterine cervix, although rarely; it accounts for 0.5-1% of all malignant tumors of the uterine cervix. A case report of an Ethiopian female presented at the Gynecology Out-Patient Clinic at Jimma University Hospital, complaining from irregular vaginal bleeding over the previous three months. Clinically there was a cauliflower cervical mass; histopathologically it was formed of sheets of small cell tumor; that further showed neuroendocrine differentiation, as demonstrated by chromogranin-A positivity. It is important to differentiate small cell carcinoma from other malignant tumors of the uterine cervix. Morphological features play an important role in making a diagnosis and the immunohistochemistry study can offer an additional useful assistance.
