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Philip Kolo, Emmanuel Sanya, James Ogunmodede, Ayodele Omotoso, Ayodele Soladoye. Normotensive offspring of hypertensive Nigerians have increased Left ventricular mass and abnormal geometric patterns. The Pan African Medical Journal. 2012;11:6 Key words: Left ventricular mass, left ventricular geometry, echocardiogram, hypertension, hypertrophy Permanent link: http://www.panafrican-med-journal.com/content/article/11/6/full Received: 04/10/2011 - Accepted: 07/11/2011 - Published: 14/01/2012 © Philip Kolo et al. The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Normotensive offspring of hypertensive Nigerians have increased Left ventricular mass and abnormal geometric patterns
Philip Kolo1, Emmanuel Sanya1, James Ogunmodede1, Ayodele Omotoso1, Ayodele Soladoye2
1Department of Medicine, University of Ilorin Teaching Hospital, P.M.B. 1459, Ilorin, Nigeria, 2Department of Physiology, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria
&Corresponding author
Dr Kolo Philip Manma, Department of Medicine, University of Ilorin Teaching Hospital, P.M.B 1459, Ilorin, Nigeria
Reports have shown that normotensive offspring of hypertensive parents (OHP) are at increased risk of developing systemic hypertension (SH) and adverse cardiovascular events later in life. The pathological antecedents of this are thought to be alterations in the structure and function of left ventricle. Therefore, the present study aimed at determining left ventricular mass and geometry in OHP and compared with offspring without parental hypertension.
Sixty-five OHP aged 15-25 years with 65-age and sex-matched offspring of normotensive parents (ONP) were studied for early makers of hypertensive cardiovascular disease. Those with heart murmurs, structural heart diseases and blood pressure ≥ 140/90 mmHg were excluded. Electrocardiography (ECG) and echocardiogram were done in standard positions.
Mean left ventricular posterior wall thickness, left ventricular mass, left ventricular mass index (LVMI) and relative wall thickness (RWT) were significantly higher in the subjects than controls (p=0.001, 0.046, 0.03 and 0.004 respectively). LVMI correlated positively with systolic and diastolic blood pressure, waist circumference (WC), ECG voltage, and posterior wall diastolic dimension. Waist circumference was an independent predictor of LVMI in OHP.
We concluded that normotensive OHP have alterations in left ventricular mass and structure; and should be considered as a special group that needs early dietary and lifestyle adjustments to prevent future cardiovascular events.
