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Jaykaran Charan, Summaiya Mulla, Sridhar Ryavanki, Naresh Kantharia. New Delhi Metallo – beta lactamase – 1 containing Enterobacteriaceae: origin, diagnosis, treatment and public health concern. The Pan African Medical Journal. 2012;11:22 Key words: Antibiotics resistance, Enterobacteriaceae, New Delhi Beta metallo lactamase, carbapenemases Permanent link: http://www.panafrican-med-journal.com/content/article/11/22/full Received: 16/05/2011 - Accepted: 11/09/2011 - Published: 13/02/2012 © Jaykaran Charan et al. The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
New Delhi Metallo – beta lactamase – 1 containing Enterobacteriaceae: Origin, Diagnosis, Treatment and Public health concern.
Jaykaran Charan1,&, Summaiya Mulla2, Sridhar Ryavanki3, Naresh Kantharia1
1Department of Pharmacology, Govt. Medical College, Surat, India, 2Department of Microbiology, Govt. Medical College, Surat, India, 3Department of Community Medicine, Govt. Medical College, Surat, India
&Corresponding author
Jaykaran Charan, Department of Pharmacology, Govt. Medical College, Outside Majura Gate, Surat (Gujarat), 395001 India
One of the biggest problems associated with the antibiotic therapy is resistance. Recently published studies have revealed that enterobacteriaceae, like E. coli and Klebsiella, isolated from several Indian centers are resistant to many antibiotics including some highly potent antibiotics like carbapenems. It has been proposed that this resistance is because of a carbapenemase enzyme called NDM- 1 (New Delhi Metallo-betalactamase - 1). This carbapenemase is class B carbapenemase also called metallolactamases as they require zinc at their active site. This enzyme is coded by a gene called bla - NDM -1 or gene NDM - 1. NDM -1 containing enterobacteriaceae can be screened in laboratory by few techniques. Metallolactamase production can be detected by disk approximation test or Modified Hodge test and NDM -1 gene can be detected by polymerase chain reaction by the use of specific primer targeting the gene. Infections caused by such bacteria are associated with high morbidity and mortality. Two classes of antibiotics i.e., polymyxins (colistin) and glycylcyclines (tigecyclines), have shown in vitro activity against NDM - 1 harboring enterobacteriaceae. The safety profile of both of these antibiotics is questionable. There is a need for active screening of microorganisms for NDM -1 and research should be directed towards the development of safe antibiotics for the treatment of these kinds of infections.
