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Maged Mohamed Refaat, Tarek Mansour Ahmed, Zeinab Ahmed Ashour, Mohamed Yousif Atia. Immunological role of nasal staphylococcus aureus carriage in patients with persistent allergic rhinitis. The Pan African Medical Journal. 2008;1:3 Key words: nasal staphylococcus, allergic rhinitis, Egypt Permanent link: http://www.panafrican-med-journal.com/content/article/1/3/full Received: 31/09/2008 - Accepted: 27/10/2008 - Published: 30/10/2008 © Maged Mohamed Refaat et al. The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Immunological role of nasal staphylococcus aureus carriage in patients with persistent allergic rhinitis
Maged Mohamed Refaat1&, Tarek Mansour Ahmed1, Zeinab Ahmed Ashour1, Mohamed Yousif Atia2
1Internal Medicine department, Ain Shams University, Cairo, Egypt; 2Allergy and Immunology Research Unit Ain Shams University, Cairo, Egypt.
& Corresponding author
Maged Mohamed Refaat, Faculty of medicine, Ain Shams University, 8 Mayo Building, Nasr Road, Nasr City, Cairo 11435, Egypt.
Abstract
Nasal carriage of staphylococcus aureus (S.aureus) exerts immunomodulatory effect in patients with atopic dermatitis and it may contribute to airway inflammation and allergic response in patients with allergic rhinitis. We Aim to investigate the frequency of nasal S.aureus carriage in patients with persistent allergic rhinitis and its possible influence on their symptoms and immune markers. We chosed 20 non smoker patients with house dust mite (HDM) allergy causing allergic rhinitis and 20 non smoker healthy subjects matched for age and sex. For all subjects rhinoscopy was done, skin prick test, nasal culture for S.aureus, nasal interleukin 4,nasal total IgE, serum total IgE and serum specific IgE(SSIgE) for HDM. Nasal S.aureus was detected in 16/20 patients (80%) and 5/20 (25%) in healthy subjects with highly significant statistical difference p<0.01. Correlation of nasal staph.aureus count and different systemic and local immune markers revealed highly significant positive correlation between nasal S.aureus count and serum total IgE (r = 0.78, p<0.01) and significant positive correlation with SSIgE (HDM) (r = 0.53, p<0.05), nasal total IgE (r = 0.39, p<0.05) and nasal IL-4 (r = 0.55, p<0.05). Nasal staph.aureus actively modulated the immune reaction in persistent allergic rhinitis patients by promoting local IgE production, so we recommend early detection and treatment of S.aureus carriage in patients.
